肽核酸（ＰｅｐｔｉｄｅＮｕｃｌｅｉｃＡｃｉｄｓ，ＰＮＡｓ），是一类用蛋白质骨架代替核酸中的磷酸核糖骨架而形成的新型分子，它不仅保留了与互补的ＤＮＡ或ＲＮＡ配对结合的特性，而且其特异性和亲和性都比相应的寡核苷酸高。同时又能抵抗所有核酸酶和蛋白酶的降解，在分子生物学和医药领域有广泛的应用前景。本文就ＰＮＡ的结构、特性以及应用等方面予以综述 Peptide Nucleic Acids (PNAs) are novel molecules formed by replacing the phosphate ribose backbone in a nucleic acid with a protein backbone that retains not only the ability to pair with complementary DNA or RNA, but also its specificity and affinity Higher than the corresponding oligonucleotide. At the same time, it can resist the degradation of all nucleases and proteases and has wide application prospect in the field of molecular biology and medicine. This article reviews the structure, characteristics and applications of PNA