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东莨菪碱系莨菪类药物,过去临床上应用较少,随着对其作用机制的研究,发现了一些新用途,现叙述如下。 1 治疗小儿重症肺炎 王慧华将小儿重症肺炎分为治疗组22例,对照组21例。两组临床资料类似。对照组常规抗感染,强心、利尿、吸氧等治疗;治疗组常规治疗加用东莨菪碱治疗。结果:治疗组与对照组比较,平喘天数、心衰、呼衰纠正时间差异非常显著。王金兰采用东莨菪碱治疗婴儿重症肺炎42例,对照组32例。两组均采用综合治疗,治疗组加用东莨菪碱0.01 mg/(kg·次)～0.03 mg/(kg·次),伴有休克者增至0.1mg/(kg·次),2次/d～3次/d,少数病例1次/d,均加入10％葡萄糖中静脉推注或静脉滴注。结果:两组差异非常显著。机制:①兴奋呼吸中枢;②缓解血管和支气管痉挛,改善通气功能;③改善微循环,预
Scopolamine-based scopolamine drugs, the clinical application of less in the past, with the study of its mechanism of action and found some new uses, are described below. A treatment of pediatric severe pneumonia Wang Huihua will be divided into severe pneumonia in children with treatment group 22 cases, control group 21 cases. Two groups of similar clinical data. Control group conventional anti-infective, cardiac, diuretic, oxygen and other treatment; treatment group with conventional treatment plus scopolamine treatment. Results: Compared with the control group, there were significant differences in the days of asthma, heart failure and respiratory failure. Wang Jinlan scopolamine treatment of 42 cases of severe pneumonia in infants, control group of 32 cases. The two groups were treated with comprehensive treatment, the treatment group scopolamine 0.01 mg / (kg · times) ~ 0.03 mg / (kg · times), with shock were increased to 0.1mg / (kg · times), 2 times / d ~ 3 times / d, a few cases 1 / d, were added 10% glucose intravenous injection or intravenous drip. Results: The differences between the two groups were significant. Mechanism: ① excite the respiratory center; ② ease blood vessels and bronchial spasm, improve ventilation function; ③ improve microcirculation, pre