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海军总医院儿科吴南海等,为探讨聚合酶链反应(PCR)技术检测白血病微小残留病(MRD)的临床应用价值及进一步提高检测效率,采用IgH和TcR_γ两个基因标志相结合的方法,运用PCR技术对18例终止治疗的儿童急性淋巴细胞白血病患儿进行了检测。 结果显示,18例患儿中检出MRD者9例,随访了1.5～102个月,9例MRD阳性者中有3例3～6个月内白血病复发,而术检出MRD的9例患儿无1例复发。提示终止治疗的白血病患儿如仍存在MRD,则有复发危险,应进行定期监测;MRD阴
Naval General Hospital Pediatrics Wu Nanhai et al. used the combination of IgH and TcR_γ gene markers to explore the clinical application value of polymerase chain reaction (PCR) for the detection of minimal residual disease (MRD) of leukemia and to further improve the detection efficiency. PCR was performed on 18 children with acute lymphoblastic leukemia who were discontinued. The results showed that 9 cases of MRD were detected in 18 cases and were followed up for 1.5 to 102 months. Among 9 cases of MRD positive, 3 cases had relapse of leukemia in 3 to 6 months, and 9 cases of MRD were detected. There was no recurrence in 1 child. If there is still MRD in children with leukemia who have stopped treatment, there is a risk of recurrence and regular monitoring should be performed; MRD