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目的探讨血清胸苷激酶1(TK1)检测对肺癌患者诊断与预后评估的意义。方法应用免疫印迹-增强化学发光法检测63例肺癌患者(A组)和14例健康体检者(B组)血清TK1水平。24例术后获随访6-18个月。其中,无肿瘤复发15例(无复发组),肿瘤复发9例(复发组);随访期同时检测了其他相关肿瘤标记物。结果 A组血清TK1水平明显高于B组[(2.37±3.74)pmol/Lvs.(0.32±0.42)pmol/L](P<0.01)。A组手术治疗后血清TK1水平显著降低(P<0.05)。复发组血清TK1均较术前升高;无复发组中1例血清TK1升高,其余14例均较术前降低。TK1与其他肿瘤标志物联合检测提高了预后评估的准确性。结论血清TK1水平升高对肺癌有辅助诊断价值,连续跟踪监测有利于肺癌治疗效果和预后的判断。
Objective To investigate the significance of serum thymidine kinase 1 (TK1) in diagnosis and prognosis of patients with lung cancer. Methods The level of serum TK1 in 63 lung cancer patients (group A) and 14 healthy subjects (group B) was detected by Western blotting and enhanced chemiluminescence. Twenty-four patients were followed up for 6-18 months. Among them, no tumor recurrence in 15 cases (no recurrence group), tumor recurrence in 9 cases (recurrence group); at the same time detect other related tumor markers. Results The level of serum TK1 in group A was significantly higher than that in group B [(2.37 ± 3.74) pmol / L vs (0.32 ± 0.42) pmol / L] (P <0.01). The level of serum TK1 in group A was significantly lower after operation (P <0.05). TK1 in the recurrent group was significantly higher than that in the non-recurrent group. One case in the non-recurrent group had an elevated serum TK1, the other 14 cases were lower than those in the preoperative group. Joint detection of TK1 and other tumor markers improves the accuracy of prognostic assessment. Conclusion Serum TK1 level has the value of auxiliary diagnosis of lung cancer, continuous follow-up monitoring is beneficial to the treatment of lung cancer and prognosis.