在离子液体[bmim]BF4中,以3-甲基-4-硝基苯甲酸甲酯为原料,经酯化、还原、酰化、硝化、还原、环合、缩合、水解反应得2-正丙基-4-甲基-6-羧基苯并咪唑,在多聚磷酸的作用下与N-甲基邻苯二胺缩合,生成的产物再与4′-溴甲基联苯-2-羧酸甲酯缩合、水解,得替米沙坦,产率93.8%,总产率在65.8%以上,精制品的HPLC质量分数达99.96%。 In ionic liquid [bmim] BF4, methyl 3-methyl-4-nitrobenzoate was esterified, reduced, acylated, nitrated, reduced, cyclized, condensed and hydrolyzed to give 2- Propyl-4-methyl-6-carboxybenzimidazole, polyphosphoric acid with N-methyl-o-phenylenediamine condensation, the resulting product and 4’-bromomethyl biphenyl-2-carboxylic acid Acid methyl ester condensation, hydrolysis, in Telmisartan, a yield of 93.8%, the total yield of 65.8% or more, the refined product HPLC mass fraction of 99.96%.