肝硬化为慢性肝病进行性纤维化的晚期,一般认为不可逆转,并将其归类为等待肝移植的严重肝病。目前,通常于病变早期经皮作肝活检确诊肝硬化。多数肝硬化病例无症状,体检时无异常发现,开始检出时是因为血清肝酶水平升高或HBV、HCV血清学阳性。 随着肝病治疗的进展,某些肝纤维化与症状明显的肝硬化病例经治疗后组织学得到改善(包括肝纤维化消退)。Hammel等报道了一组行阻塞性胆管减压术的肝纤维化患者,并将手术前后肝活检标本进行比较,发 Cirrhosis is a late stage of progressive fibrosis of chronic liver disease and is generally considered irreversible and is classified as a serious liver disease awaiting liver transplantation. At present, liver cirrhosis is usually diagnosed by percutaneous transhepatic biopsy early in the lesion. Most cases of liver cirrhosis asymptomatic, no abnormalities found during physical examination, began to check out because of elevated serum liver enzyme levels or HBV, HCV seropositivity. With the progress of liver disease, some patients with liver fibrosis and obvious symptoms of liver cirrhosis after histological improvement (including the regression of liver fibrosis). Hammel reported a group of patients with obstructive bile duct decompression of liver fibrosis and liver biopsy specimens before and after comparison, hair