同型半胱氨酸是蛋氨酸代谢的中间产物 ,它的生理作用是维持体内含硫氨基酸的平衡。近年来的研究显示 ,血浆同型半胱氨酸水平的升高与血管疾病有关。糖尿病的慢性并发症主要是血管病变 ,但其血管病变的机制至今尚未完全阐明。血浆胰岛素水平可能会通过影响同型半胱氨酸代谢而导致血管病变。高同型半胱氨酸血症与糖尿病大血管病变的发生有关 ,与微血管病变亦可能有一定关系。可能是通过影响血管内皮细胞的结构和功能 ,影响血管平滑肌和血凝系统而导致血管病变的产生 ,并加速其发展 Homocysteine ​​is an intermediate of methionine metabolism and its physiological role is to maintain the balance of sulfur-containing amino acids in the body. In recent years, studies have shown that plasma homocysteine ​​levels and vascular disease related. Chronic complications of diabetes is mainly vascular disease, but the mechanism of its vascular lesions has not yet been fully elucidated. Plasma insulin levels may cause vascular lesions by affecting homocysteine ​​metabolism. Hyperhomocysteinemia is associated with the development of diabetic macroangiopathy and may also have a relationship with microvascular disease. May affect the structure and function of vascular endothelial cells, affecting vascular smooth muscle and blood coagulation system and lead to the occurrence of vascular lesions and accelerate its development