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目的:探讨T细胞亚群检测对儿童传染性单核细胞增多症的诊断价值。方法:选择儿童传染性单核细胞增多症60例为观察组,另选择同期门诊体检健康儿童20例对照组。采用酶联免疫吸附试验(ELISA)检测两组T细胞亚群CD3~+、CD4~+、CD8~+的表达率,并比较两组的差异。结果:观察组CD3~+、CD8~+细胞表达率显著高于对照组(P<0.05),CD4~+细胞表达率、CD4~+/CD8~+比值显著或非常显著低于对照组(P<0.05,P<0.01)。结论:传染性单核细胞增多症患儿存在免疫功能异常;CD3~+、CD4~+、CD8~+细胞表达率检测对诊断传染性单核细胞增多症具有重要参考价值。
Objective: To investigate the diagnostic value of detecting T cell subsets in children with infectious mononucleosis. Methods: Sixty children with infectious mononucleosis were selected as the observation group, and another 20 healthy children were selected as the control group during the same period. The expression of CD3 +, CD4 +, CD8 + in T lymphocyte subsets of the two groups was detected by enzyme-linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Results: The expression rates of CD3 ~ + and CD8 ~ + in the observation group were significantly higher than those in the control group (P <0.05). The positive rate of CD4 ~ + cells and the ratio of CD4 ~ + / CD8 ~ <0.05, P <0.01). CONCLUSION: Infectious mononucleosis patients have abnormal immune function. The detection of CD3 +, CD4 +, CD8 + cell expression is of important value in the diagnosis of infectious mononucleosis.