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目的 了解西安地区胃肠疾病患者幽门螺杆菌的感染率及对常用抗菌素的敏感性 ,为幽门螺杆感染治疗的药物选择提供依据 .方法 采用细菌培养的方法对 2 5 9例胃肠疾病患者胃粘膜活检标本进行了幽门螺杆菌的分离鉴定 ,并用琼脂稀释和浓度梯度法对随机抽取的 5 0株幽门螺杆菌进行了抗生素敏感性试验 .结果 西安地区胃肠疾病患者幽门螺杆菌的感染率为 74% ,其中胃癌的感染率为 5 8% ;胃溃疡的感染率为 75 % ;十二指肠溃疡的感染率为 95 % ;其他胃肠疾病也有不同的感染率 ,幽门螺杆菌对阿莫西林和克拉霉素的敏感率均为 10 0 % ,两种检测方法无差异 .幽门螺杆菌对甲硝唑的耐药率较高 ,琼脂稀释法为 38% ,浓度梯度法为 5 8% ,存在一定的差异 .结论 幽门螺杆菌是胃肠疾病发生的重要因素 ,在西安地区阿莫西林和克拉霉素是治疗幽门螺杆菌感染的首选药物 ,控制甲硝唑在治疗幽门螺杆菌感染中的使用 .在进行幽门螺杆菌对甲硝唑的敏感试验时 ,应采取琼脂稀释和浓度梯度两种方法 ,以提高耐药菌的检出
Objective To understand the prevalence of Helicobacter pylori and its susceptibility to common antibiotics in patients with gastrointestinal diseases in Xi’an and to provide evidence for the selection of drugs for the treatment of pyloric screw infection.Methods Bacterial culture was used to detect the gastric mucosa in 259 patients with gastrointestinal diseases Biopsy specimens of Helicobacter pylori isolation and identification, and the use of agar dilution and concentration gradient method of 50 randomly selected strains of Helicobacter pylori antibiotic susceptibility test results in Xi’an, gastrointestinal diseases Helicobacter pylori infection rate was 74 %, Of which gastric cancer infection rate was 58%; gastric ulcer infection rate was 75%; duodenal ulcer infection rate was 95%; other gastrointestinal diseases have different infection rates, Helicobacter pylori infection of amoxicillin And clarithromycin were 10 0%, no difference between the two detection methods.Helicobacter pylori resistance to metronidazole was higher, the agar dilution method was 38%, the concentration gradient method was 58%, there A certain difference.Conclusion Helicobacter pylori is an important factor in the occurrence of gastrointestinal diseases, amoxicillin and clarithromycin in Xi’an is the drug of choice for the treatment of Helicobacter pylori infection, control Metronidazole in the treatment of Helicobacter pylori infection in the use of H. pylori sensitive test of metronidazole, agar dilution and concentration gradient should be taken two methods to improve the detection of resistant bacteria