胃肠肽类的研究已有不少进展 ,脑肠肽是具有特殊生物作用的活性物质 ,目前已知的脑肠肽已有数十种 ,其生理作用相当复杂 ,为研究大肠癌患者粘膜、血清中某些肽类的变化 ,我们应用放射免疫法联合测定大肠癌患者粘膜及血清中β-内啡肽（β-ＥＰ）、Ｐ物质（ＳＰ）、血管活性肠肽 Gastrointestinal peptide research has made a lot of progress, ghrelin is a special biological activity of the active substance, there are now dozens of brain gut peptides, its physiological role is quite complex, for the study of patients with colorectal mucosa, Serum levels of certain peptides, we used radioimmunoassay in patients with colorectal cancer mucosa and serum β-endorphin (β-EP), substance P (SP), vasoactive intestinal peptide