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目的:对非甲～戊型病毒性肝炎患者的血清病原学进行探讨。方法:用酶联免疫吸附法(ELISA)和PCR法检测36例非甲～戊型病毒性肝炎患者血清的病毒标记物。结果:庚型肝炎病毒抗体(抗HGV)阳性率为19%,庚型肝炎病毒核糖核酸(HGVRNA)阳性率为36%;抗巨细胞病毒免疫球蛋白M(抗CMVIgM)和抗EB病毒免疫球蛋白M(抗EBVIgM)均阴性;输血后肝炎相关病毒DNA(TTVDNA)阳性率为31%,TTVDNA阳性者的PCR产物与日本株N22的同源性为95%。结论:TTV、HGV感染在乌鲁木齐地区病毒性肝炎患者中占有相当比例,并同时存在不明致病因子感染,应当引起广大医务工作者的重视。
Objective: To investigate the serum etiology of patients with non-A-type hepatitis. Methods: Serum viral markers in 36 patients with non-A-type hepatitis were detected by enzyme linked immunosorbent assay (ELISA) and PCR. Results: The positive rate of hepatitis G virus antibody (anti- HGV) was 19%, and the positive rate of GGV RNA was 36%. Anti-cytomegalovirus immunoglobulin M (antiCMV IgG) and anti-EB virus Immunoglobulin M (anti-EBVIgM) were negative. The positive rate of hepatitis B virus (TTVDNA) was 31% after transfusion, and 95% of the TTVDNA-positive products were PCR products from Japanese strain N22. Conclusions: TTV and HGV infection account for a considerable proportion of patients with viral hepatitis in Urumqi region. Infection with unknown virulence factors may also occur at the same time, which should be paid more attention to by medical professionals.