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目的探讨子宫内膜异位症(EMs)腹腔镜术后应用促性腺激素释放激素激动剂(GnRH-a)的临床效果。方法选择腹腔镜手术治疗的120例子宫内膜异位囊肿患者采用随机数字表法分为研究组和对照组各60例,两组患者术后均给予相同的常规治疗方法,研究组同时给予GnRH-a治疗,治疗时间3个月,对比两组患者生殖激素水平、痛经程度评分、2年复发率及不良反应发生率。结果治疗前,研究组和对照组的FSH、LH、E2水平、VAS评分比较差异无统计学意义(P>0.05);治疗后,两组患者的血清FSH、LH、E2水平、VAS评分较治疗前均显著的降低,且研究组显著的低于对照组,差异均有统计学意义(P<0.05)。术后2年,研究组的复发率6.67%显著低于对照组的18.33%,差异有统计学意义(P<0.05)。治疗过程中,研究组的不良反应发生率16.67%显著高于对照组的5.00%,差异有统计学意义(P<0.05)。结论 EMs腹腔镜术后应用GnRH-a治疗有助于降低患者的生殖激素水平、降低复发率,但是治疗过程中应该注意药物的不良反应。
Objective To investigate the clinical effect of GnRH-a in patients with endometriosis (EMs) after laparoscopic surgery. Methods 120 patients with endometriosis treated by laparoscopic surgery were randomly divided into study group and control group with 60 cases in each group. The patients in both groups were given the same routine treatment after operation. The study group was given GnRH -a treatment, the treatment time of 3 months, compared two groups of patients reproductive hormone levels, grade of dysmenorrhea, 2-year recurrence rate and adverse reaction rate. Results Before treatment, the levels of FSH, LH and E2 in study group and control group had no significant difference in VAS score (P> 0.05). After treatment, serum FSH, LH, E2 levels and VAS scores (P <0.05). The differences between the two groups were statistically significant (P <0.05). At 2 years after operation, the recurrence rate of the study group was significantly lower than that of the control group (6.67% vs 18.33%, P <0.05). During the course of treatment, the incidence of adverse reactions in the study group was significantly higher than that in the control group (16.67% vs 5.00%, P <0.05). Conclusion The application of GnRH-a after laparoscopic EMs is helpful to reduce the level of reproductive hormones and reduce the recurrence rate in patients with EMs. However, the adverse reactions of drugs should be noticed in the course of treatment.