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用微生物法和高效液相色谱法研究了18例急性细菌感染患者静脉推注国产头孢噻肟钠1g静注后的临床药动学。结果显示:该药静脉推注后的药动学符合二室开放模型。用两种方法在肝、肾功能正常患者中所测结果基本一致。肝、肾功能正常时消除相半衰期(t1/2β)较短(分别为0.88与1.01小时),多次给药后无蓄积。严重肾功不全时半衰期明显延长,血中有药物蓄积。单纯肝功不全对药动学影响不大。感染中毒性休克时本药的分布,消除速率均减慢。
The clinical pharmacokinetics of intravenous cefotaxime sodium 1g intravenous injection in 18 patients with acute bacterial infection was studied by microbiological method and high performance liquid chromatography. The results showed that the pharmacokinetics of the drug after intravenous bolus accorded with two-compartment open model. With the two methods in liver and kidney function in patients with normal test results are basically the same. The elimination half-life (t1 / 2β) was short (0.88 and 1.01 hours, respectively) with normal hepatic and renal function and no accumulation after multiple administrations. Serious renal failure significantly prolonged half-life, blood accumulation of drugs. Simple liver dysfunction has little effect on pharmacokinetics. Infection with toxic shock distribution of the drug, the elimination rate are slowed.