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目的：观察胃癌患者血清Ⅳ型胶原（ＣｏｌⅣ）含量变化及其与肿瘤浸润及转移的关系。方法：应用放射免疫方法测定２０例胃癌患者血清ＣｏｌⅣ含量，并探讨其与胃癌ＴＮＭ分期、淋巴结转移的关系。结果：肿瘤组血清ＣｏｌⅣ含量明显高于对照组（Ｐ＜０．０１）；ＴＮＭ分期中，Ⅱ，Ⅳ期组血清ＣｏｌⅣ含量显著高于Ⅰ期组（Ｐ＜０．０５）；淋巴结转移组显著高于无淋巴结转移组（Ｐ＜０．０１）。结论：胃癌患者血清ＣｏｌⅣ含量变化与肿瘤的浸润及转移等生物学行为密切相关，观察血清ＣｏｌⅣ含量及其变化，对胃癌患者的病情及预后判断有一定的参考价值
Objective: To observe the changes of serum type IV collagen (Col IV) in patients with gastric cancer and its relationship with tumor invasion and metastasis. METHODS: Serum Col IV levels in 20 patients with gastric cancer were measured by radioimmunoassay, and their relationship with TNM staging and lymph node metastasis was explored. Results: The serum Col IV content in the tumor group was significantly higher than that in the control group (P<0.01). In the TNM stage, the serum Col IV content in the II and IV groups was significantly higher than that in the stage I group (P<0.05); the lymph node metastasis group was significantly Higher than those without lymph node metastasis (P<0.01). Conclusion: The changes of serum Col IV in patients with gastric cancer are closely related to the biological behavior such as tumor invasion and metastasis. Observing the serum Col IV content and its changes have a certain reference value for the patient’s condition and prognosis of gastric cancer.