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目的：探讨ＣＤ４４Ｖ６与胃癌发生及胃癌生物学行为的关系。方法：应用免疫组化Ｓ－Ｐ方法研究１０例胃粘膜肠化及４６例胃癌的ＣＤ４４Ｖ６表达。结果：胃粘膜肠化及胃癌阳性率分别为１０％和６３％，淋巴结转移组阳性率（７５％）明显高于非转移组（４５％，Ｐ＜０．０５），且ＣＤ４４Ｖ６表达与Ｌａｕｒｅｎ分型相关。结论：ＣＤ４４Ｖ６分子参与肿瘤发生、发展
Objective: To investigate the relationship between CD44V6 and the occurrence of gastric cancer and the biological behavior of gastric cancer. Methods: Immunohistochemical S-P method was used to study the expression of CD44V6 in 10 cases of gastric mucosal intestine and 46 cases of gastric cancer. Results: The positive rates of gastric mucosal intestine and gastric cancer were 10% and 63%, respectively. The positive rate in lymph node metastasis group (75%) was significantly higher than that in non-metastasis group (45%, P<0.05), and the expression of CD44V6 was associated with Lauren’s score. Type related. Conclusion: CD44V6 is involved in tumorigenesis and development