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目的：探讨哮喘患儿血浆内皮素和心钠素的变化。方法：采用放射免疫测定血浆内皮素和心钠素水平。结果：４８例哮喘患儿发作期血浆内皮素和心钠素水平均明显增高，稳定期时下降，其中血浆心钠素与对照组相近，但血浆内皮素水平仍高于对照组；内、外源型哮喘患儿血浆内皮素、心钠素水平无显著性差异；哮喘患儿血浆内皮素与心钠素水平正相关关系。结论：哮喘时血浆内皮素和心钠素水平的变化及相关关系可能是机体的一种调节机制并在其病理生理过程中起重要作用。
Objective: To investigate the changes of plasma endothelin and atrial natriuretic peptide in children with asthma. Methods: Plasma endothelin and atrial natriuretic peptide levels were determined by radioimmunoassay. Results: The plasma levels of endothelin and atrial natriuretic peptide were significantly increased in 48 asthmatic children and decreased in stable phase. The plasma atrial natriuretic peptide was similar to the control group, but the plasma endothelin level was still higher than that of the control group There was no significant difference in plasma endothelin and atrial natriuretic peptide in asthmatic children with asthma, and there was a positive correlation between plasma endothelin and atrial natriuretic peptide in children with asthma. CONCLUSIONS: The changes of plasma endothelin and atrial natriuretic peptide levels in asthma may be a regulatory mechanism of the body and play an important role in the pathophysiological process.