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目的:观察健脾利湿方中药联合双歧三联活菌胶囊治疗溃疡性结肠炎的疗效,及对患者炎性因子的影响。方法:将确诊为溃疡性结肠炎的患者55例,随机分为治疗组30例和对照组25例,治疗组给予健脾利湿方中药结合双歧三联活菌胶囊治疗,对照组只给予双歧三联活菌胶囊治疗。观察2组患者连续给药30天后的临床疗效、临床症状评分,测定炎性因子肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8和炎性抑制因子IL-10的含量。结果:临床疗效总有效率治疗组为83.33%,对照组为68.00%,2组总有效率比较,差异有显著性意义(P<0.05)。治疗后,2组患者临床症状总评分均较治疗前降低,差异均有非常显著性意义(P<0.01)。2组治疗后临床症状总评分比较,治疗组低于对照组,差异有非常显著性意义(P<0.01)。治疗后,2组TNF-α、IL-8含量较治疗前下降显著,IL-10含量较治疗前升高,差异均有显著性意义(P<0.05);治疗后2组3项指标分别比较,差异均有显著性意义(P<0.05)。结论:健脾利湿方中药联合双歧三联活菌胶囊治疗溃疡性结肠炎疗效确定,并能影响患者体内炎性因子的水平。
Objective: To observe the curative effect of traditional Chinese medicine combined with bifidobacterium and triple joint live capsule in the treatment of ulcerative colitis and its effect on inflammatory factors. Methods: Fifty-five patients diagnosed as ulcerative colitis were randomly divided into treatment group (n = 30) and control group (n = 25). The treatment group was given Jianpi Lishi decoction combined with bifidus triple viable capsule, while the control group received only double Qi triple live bacteria capsule treatment. The clinical curative effect and clinical symptom score of 30 days after continuous administration were observed in two groups. The levels of tumor necrosis factor-α (TNF-α), interleukin (IL) -8 and inflammatory cytokines IL-10 . Results: The total effective rate of the clinical curative effect was 83.33% in the treatment group and 68.00% in the control group. The total effective rate in the two groups was significantly different (P <0.05). After treatment, the total scores of clinical symptoms in both groups were lower than those before treatment, with significant differences (P <0.01). The total scores of clinical symptoms in the two groups were significantly lower than those in the control group (P <0.01). After treatment, the levels of TNF-α and IL-8 in the two groups decreased significantly compared with those before treatment, and the levels of IL-10 in the two groups were significantly higher than those before treatment (P <0.05). After treatment, the indexes of three groups were compared , The differences were significant (P <0.05). Conclusion: The therapeutic effect of traditional Chinese medicine combined with bifidus triplex capsule in treatment of ulcerative colitis is confirmed and it can affect the level of inflammatory cytokines in patients.