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Epilepsy is a common neurological disorder characterized by recurrent seizures.Most antiepileptic drugs(AEDs)work by regulating the balance of the excitatory gluta-matergic and inhibitory GABAergic transmission.How-ever,the current AEDs cannot successfully control seizures in most(＞70％)patients with temporal lobe epilepsy(TLE)[1],in whom seizures typically begin in the hippocampus.