十年前,Smith和Halls已经论证指出,大肠杆菌的某些菌株产生一种能够引出聚积在已经结扎的动物肠袢内的液体的有过滤作用的物质。Gyles进一步叙述了两种大肠杆菌的肠毒素:一种是能透析的耐热的毒素,另一种是具有较大分子的非透析的相对不耐热的肠毒素。许多研究者后来进行广泛的研究结果已经证实了上述两种肠毒素具有 Ten years ago, Smith and Halls argued that certain strains of E. coli produce a filtered substance that can elicit a liquid that accumulates in the intestine of an already ligation animal. Gyles further describes two enterotoxigenic Escherichia coli strains: one is a dialyzing thermotolerant toxin and the other is a non-dialyzed, relatively thermolabile enterotoxin with larger molecules. Many researchers later conducted extensive studies that have confirmed that the two enterotoxins have