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目的观察右美托咪定与咪达唑仑对小儿气管异物取出术患儿生命体征的影响,检测患儿体内炎性反应因子的变化情况。方法 100例符合入选标准的气管异物取出术患儿,随机分为右美托咪定组和咪达唑仑组,每组各50例,分别在麻醉诱导前10 min静脉输注右美托咪定0.8μg/kg或咪达唑仑0.1mg/kg。术中高频射流呼吸机给氧,保留患儿自主呼吸,面罩吸入七氟烷维持麻醉,放免法对比麻醉前、手术开始1min、手术结束后3个时间段两组患儿外周血白介素-1、白介素-6含量的差异。结果两组患儿生命体征无明显差异(P>0.05):两组间白介素-1、白介素-6含量的差异有统计学意义(P<0.05)。结论右美托咪定与咪达唑仑都能够安全应用于小儿气管异物取出术的麻醉,同时右美托咪定能够更好地减轻机体的炎症反应。
Objective To observe the effect of dexmedetomidine and midazolam on the vital signs in children with tracheal foreign body removal and to detect the change of inflammatory response in children. Methods A total of 100 children with tracheal foreign bodies who met the inclusion criteria were randomly divided into dexmedetomidine group and midazolam group, with 50 patients in each group. Patients were given intravenous dexmedetomidine Set 0.8μg / kg or midazolam 0.1mg / kg. Intraoperative high-frequency jet ventilator oxygen, leaving children with spontaneous breathing, mask inhalation of sevoflurane to maintain anesthesia, radioimmunotherapy before anesthesia, the beginning of surgery 1min, 3 hours after surgery, the two groups of children with interleukin-1, Differences in interleukin-6 levels. Results There was no significant difference in vital signs between the two groups (P> 0.05). There was significant difference in the levels of interleukin-1 and interleukin-6 between the two groups (P <0.05). Conclusion Both dexmedetomidine and midazolam can be safely applied to pediatric tracheal aspiration, while dexmedetomidine can reduce the body’s inflammatory response.