在实验室首次让长爪沙鼠和小白鼠进行杂交，得MKG杂交小鼠。从东乡伊蚊体内收集周期型马来丝虫感染或幼虫200～250条注入杂交鼠腹腔内，125～284d在12只杂交鼠腹腔抽液中4只检获微丝蚴，密度为5～353条／60μl，其形态大小与沙鼠和人体内的无可见差异。感染30～165d的16只杂交小鼠，解剖9只，有6只检获丝虫是虫或成虫。实验感染率为56.25％（9／16）。丝虫杂交鼠模型的建立，为丝虫生物学、病理学、免疫化学、新药筛选和分子生物学（DNA探针）等研究开辟新的途径。 For the first time in the laboratory, Mongolian gerbils and mice are crossed to obtain MKG mice. Cyclospora cercariae were collected from Dongxiang Aedes mosquitoes or 200 ~ 250 larvae were injected into the peritoneal cavity of mice. After 125 ~ 284 days, 4 microfilariae of 12 hybrid mice were inoculated intraperitoneally and the density was 5 ~ 353 / 60μl, its shape and size and no difference between gerbils and human body. Sixteen crossed mice from 30 to 165 days were dissected and 9 were dissected. Six were found to be worms or adults. Experimental infection rate was 56.25% (9/16). The establishment of the silkworm crossbred rat model opens up new avenues for the study of filarial biology, pathology, immunochemistry, new drug screening and molecular biology (DNA probes).