目的：研究端粒酶（ＴＬＭＡ）在鼻咽癌（ＮＰＣ）中的表达。方法：采用ＴＲＡＰＰＣＲＥＬＩＳＡ法探讨１８例ＮＰＣ，２例放疗后ＮＰＣ，４例癌旁组织及４例慢性鼻咽炎鼻咽部活检组织中ＴＬＭＡ表达。结果：１８例ＮＰＣＴＬＭＡ阳性率为８８．９％。４例癌旁组织阳性率为７５．０％，慢性鼻咽炎全部为阴性。１例复发性ＮＰＣ为阳性，１例疗后未复发为阴性。ＴＬＭＡ表达与ＮＰＣ分期、颈淋巴结转移似无明显关系。结论：ＴＬＭＡ在ＮＰＣ及癌旁组织中均有高表达 Objective: To study the expression of telomerase (TLMA) in nasopharyngeal carcinoma (NPC). METHODS: The expression of TLMA in 18 cases of NPC, 2 cases of NPC after radiotherapy, 4 cases of paracancerous tissue and 4 cases of chronic nasopharyngitis nasopharynx biopsy were studied by TRAP PCR ELISA. Results: The positive rate of NPCTLMA was 88.9% in 18 cases. The positive rate of paracancerous tissues in 4 cases was 75.0%, and all of chronic nasopharyngitis were negative. One case of recurrent NPC was positive, and one case was not negative after treatment. There was no significant relationship between TLMA expression and NPC staging and cervical lymph node metastasis. Conclusion: TLMA is highly expressed in both NPC and adjacent tissues