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为探讨增殖细胞核抗原 ( Proliferating cell nuclear antigen,PCNA)在胃癌的表达与淋巴结转移及预后的关系 ,采用免疫组化法 ( ABC法 )测定 94例胃癌石蜡包埋标本。结果 :1胃粘膜不同病理状态下 PCNA指数差异显著 ( P <0 .0 1 ) ;2PCNA指数同患者的性别和年龄无关 ( P >0 .0 5 ) ,与肿瘤的生长方式、组织类型、浆膜层受侵与否、淋巴结转移与否和临床分期关系密切 ( P <0 .0 5 ) ;3PCNA指数与胃癌的预后密切相关 ( P <0 .0 5 ) ,弱级 ( 1～ 2级 )表达的患者预后较好 ,提示 PCNA检测可作为判断胃癌生物学行为和预后的一项良好指标。
To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) in gastric cancer and lymph node metastasis and prognosis, 94 cases of paraffin-embedded specimens of gastric cancer were detected by immunohistochemical method (ABC method). Results: 1 There was significant difference in PCNA index in gastric mucosa under different pathological conditions (P < 0.01); 2PCNA index was not related to the gender and age of patients (P > 0.05), and the growth pattern, tissue type, and plasma of tumors. Whether the membrane was invaded or not, lymph node metastasis was closely related to clinical stage (P < 0.05); 3PCNA index was closely related to the prognosis of gastric cancer (P <0.05), weak grade (Grades 1 to 2). The patient’s prognosis is better, suggesting that PCNA detection can be used as a good indicator to determine the biological behavior and prognosis of gastric cancer.