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INTRODUCTION The primary physiological function of calcitonin, apeptide hormone secreted from C-cells of the thyroidgland, is to modulate plasma Ca~(2+) concentrations via itsactions on bone and kidney. The hypocalcemic effectof calcitonin is mainly caused by inhibition of osteoclasticbone resorption which is mediated by cyclic AMP-dependent protein kinase (PKA). Calcitonin can beused for treatment of metabolic bone disorders including
INTRODUCTION The primary physiological function of calcitonin, apeptide hormone secreted from C-cells of the thyroid gland, is to modulate plasma Ca ~ (2+) concentrations via itsactions on bone and kidney. The hypocalcemic effectof calcitonin is mainly caused by inhibition of osteoclasticbone resorption which is mediated by cyclic AMP-dependent protein kinase (PKA). Calcitonin can be used for treatment of metabolic bone disorders including