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目的观察抑癌基因PTEN在结肠癌组织中的表达,探讨其与结肠癌发生的关系及其临床意义。方法采用免疫组织化学S-P法检测抑癌基因PTEN在结肠癌组织和正常结肠黏膜中的表达。结果 PTEN在正常结肠黏膜和结肠癌中阳性率分别为100.0%,64.7%。PTEN表达与结肠癌的分化程度高低、浸润深度、是否有淋巴结转移关系密切,差异均有统计学意义(P<0.05)。结论 PTEN的异常表达可为结肠癌诊断和预后提供科学依据。
Objective To observe the expression of tumor suppressor gene PTEN in colon cancer tissues and to explore its relationship with the development of colon cancer and its clinical significance. Methods Immunohistochemical S-P method was used to detect the expression of tumor suppressor gene PTEN in colon cancer tissues and normal colon mucosa. Results The positive rates of PTEN in normal colorectal mucosa and colon cancer were 100.0% and 64.7%, respectively. The expression of PTEN was closely related to the differentiation, depth of invasion and lymph node metastasis of colorectal cancer (P <0.05). Conclusion The abnormal expression of PTEN may provide a scientific basis for the diagnosis and prognosis of colon cancer.