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用13只兔研究了iv去甲肾上腺素(NE,0.98～125μg/kg)和硝普钠(SNP,7.81～500μg/kg)升降压作用的量反应和时反应量-效关系(TDRR),发现兔动脉压浓度依赖性地为NE升高而被SNP降低(P<0.01),其作用的潜伏期和时程也呈现浓度依赖性的量-效关系,用双曲线型四参数模型ⅡY=C~(s+1)/(|InX-a|)~s+b进行加权的非线性最小二乘法拟合,得NE时程的参数为a=6.6924,b=-24.3335,c=22.5431,s=0.9701,而
Thirteen rabbits were used to study the volume response and the time-dependent dose-response relationship (TDRR) for the antihypertensive effect of iv norepinephrine (NE, 0.98-125 μg / kg) and sodium nitroprusside (SNP, 7.81-500 μg / (P <0.01). The latency and duration of action were also dose-dependent in a dose-dependent manner. Hyperbolic four-parameter model ⅡY = The nonlinear least-squares fitting method of weighting C ~ (s + 1) / (| InX-a |) ~ s + b gives the parameters of NE time-history are a = 6.6924, b = -24.3335, c = 22.5431, s = 0.9701, and