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目的 探讨BSD2 0 0 0型热疗机深部立体聚焦热疗结合放射治疗盆腔恶性肿瘤的疗效。方法 自 1995年8月至 1997年 12月我们将 6 1例盆腔复发或转移的恶性肿瘤病人随机分为热疗加放疗组 ( 3 1例 )和单纯放疗组 ( 3 0例 )。热疗采用立体聚焦的BSD2 0 0 0型热疗机 ,Sigma6 0辐射器 ,每周热疗两次 ,每次均于同日放疗后 3 0分钟内进行 ,每次 40～ 6 0分钟。平均每例热疗 3 .5次。采用高电阻铅测温针肿瘤内测温。放疗用 6MV或 15MVx线 ,每周 5次 ,每次 1.8～ 2 .0Gy ,三野或四野照射 ,均用缩野技术。热疗加放疗组平均照射 5 6Gy ,单纯放疗组 6 0 .5Gy。 结果 治疗结束后热疗加放疗组CR率为 6 4 .5 % ;单纯放疗组为 3 3 .3 3 % (P <0 .0 5 )。放疗至 2 0Gy时两组的CR +PR率即显示有明显的意义(P <0 .0 5 )。当放疗至 40Gy时热疗加放疗组的CR率即达 5 5 .2 % ,明显高于单纯放疗组 ( 2 3 .3 % )P <0 .0 5。热疗加放疗组的副作用包括加热区域疼痛 ,股外侧烧灼样感 ,脉搏增快 ,血压升高 ,皮肤水疱。两组皮肤反应均低于Ⅱ°。发生率两组无明显差异 (分别为 2 2 .6 % ,16 .7% )。结论 采用BSD2 0 0 0型深部立体聚焦热疗机热疗结合放疗可以明显提高盆腔复发或转移恶性肿瘤的疗效 ,减少放疗的并发症。
Objective To investigate the efficacy of deep stereoscopic focused hyperthermia combined with radiotherapy in the treatment of pelvic malignant tumors with BSD200 type hyperthermia machine. Methods From August 1995 to December 1997, 61 patients with malignant tumor of recurrent or recurrent pelvic tumors were randomly divided into hyperthermia plus radiotherapy group (31 cases) and radiotherapy alone group (30 cases). Hyperthermia using stereoscopic BSD200 type hyperthermia machine, Sigma60 radiators, twice a week hyperthermia, each on the same day 30 minutes after radiotherapy, each 40 ~ 60 minutes. Each case of hyperthermia 3.5 times. Using high-resistance lead thermometer needle tumor temperature measurement. Radiotherapy with 6MV or 15MVx line, 5 times a week, each 1.8 ~ 2.0Gy, San Ye or Shonai irradiation, are using shrinking technology. Radiotherapy plus radiotherapy group average irradiation 5 6Gy, radiotherapy alone group 60.5Gy. Results After the treatment, the CR rate of the hyperthermia plus radiotherapy group was 64.5%, while the radiotherapy alone group was 33.33% (P <0.05). Radiotherapy to 20Gy CR + PR rate of both groups showed significant (P <0. 05). When radiotherapy to 40Gy hyperthermia plus radiotherapy group CR rate of up to 55.2%, significantly higher than the radiotherapy alone group (23.3%) P <0. Side effects of hyperthermia plus radiotherapy included pain in the heating area, burning sensation on the outside of the femoral head, increased pulse rate, elevated blood pressure, and blistering of the skin. Skin reaction in both groups was lower than Ⅱ °. There was no significant difference in incidence between the two groups (22.6%, 16.7%, respectively). Conclusion BSD200 type deep three-dimensional hyperthermia combined hyperthermia with radiotherapy can significantly improve the efficacy of pelvic recurrent or metastatic malignancies and reduce the complications of radiotherapy.