目的观察促性腺激素释放激素类似物（ＧｎＲＨａ）和甲孕酮用于治疗真性性早熟女孩，对其抑制性发育，减慢骨成熟和生长速度，改善成人期预测身高的作用。方法分别使用两种药物治疗两组特发性真性性早熟女孩各９例，时间６～１２个月，观察治疗前后的身高、性发育情况、骨龄、成人期预测身高等，并进行综合比较。结果两组患儿经治疗后，性发育情况大多数得到抑制。甲孕酮治疗组骨龄年增长为１１岁，身高年增长为７６ｃｍ，成人期预测身高治疗前后无改变。长效ＧｎＲＨａ组骨龄年增长为０２岁，身高年增长为５６ｃｍ，成人期预测身高治疗６个月时增长３１ｃｍ，较治疗前明显改善（Ｐ＜００１），治疗１年时增长６４ｃｍ，较治疗６个月时更为明显（Ｐ＜００５）。结论长效ＧｎＲＨａ与甲孕酮相比较，除可抑制性发育进程外，还可有效减慢骨成熟和生长速度，最终改善成人期预测身高，治疗时间愈长，效果愈明显 Objective To observe the effect of gonadotropin-releasing hormone analogue (GnRHa) and medroxyprogesterone acetate in the treatment of precocious puberty girls on their inhibitory development, slowing the rate of bone maturation and growth, and improving their predictive height in adulthood. Methods Nine kinds of idiopathic precocious puberty girls were treated with two drugs respectively, with a duration of 6 to 12 months. The height, sexual development, bone age and adult height were observed before and after treatment. The comparisons were made between the two groups. Results After treatment, most of the sexual development was suppressed in both groups. Median progesterone treatment group, the growth of bone age was 1  1 years old, height growth was 7  6cm, adult height before and after treatment no change. In the long-term GnRHa group, the bone age increased by 0.2 years and the height increased by 5.6 years. The adult height increased by 31 cm after 6 months of height treatment, which was significantly improved compared with that before treatment (P <001) Year increase of 6  4cm, 6-month treatment more obvious (P <0  05). Conclusion Long-acting GnRHa, compared with medroxyprogesterone acetate, can not only inhibit the developmental process, but also effectively reduce the bone maturation and growth rate, and ultimately improve the predictive height of adult. The longer the treatment time, the more obvious the effect