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由于具有高效靶向药物传递的潜力,病毒颗粒已成为药物和生命科学领域的研究焦点.病毒颗粒具有病毒性载体和非病毒性载体的优点,同时克服了两者的局限性.病毒颗粒药物传递系统具有无毒、生物相容性、生物可降解性和非自动免疫等特点.研究表明,病毒颗粒能够在细胞间转运多种具有生物活性的分子,例如核酸或者基因、多肽、蛋白质以及其它抗癌药物等,因此在疾病治疗方面可能具有重要作用.如何制备携带有生物活性材料和治疗试剂的病毒颗粒和确定病毒颗粒药物的最佳剂型是目前该领域中挑战性的课题.本文综述了病毒颗粒技术多方面的特征及应用前景.
Due to its potential to efficiently target drug delivery, viral particles have become the focus of research in the fields of medicine and life sciences, and viral particles have the advantages of both viral and non-viral vectors while overcoming the limitations of both.Viral particle drug delivery The system has the characteristics of non-toxicity, biocompatibility, biodegradability and non-autoimmunity, etc. The research shows that the virus particles can transport a variety of biologically active molecules, such as nucleic acids or genes, polypeptides, proteins and other antigens Cancer drugs, etc. Therefore, it may play an important role in the treatment of diseases.How to prepare virus particles carrying biological active materials and therapeutic agents and to determine the optimal dosage form of virus particle drugs are the current challenging topics in the field.This paper reviews the progress of the virus Many aspects of particle technology and its application prospects.