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目的研究青少年强直性脊柱炎(ankylosingspondylitis,AS)早期年龄、身高、体质量、体质量指数(BMI)与L1-4骨矿含量(L1-4BMC)、L1-4面积骨密度(L1-4BMD)、L1-4体积表观骨密度(L1-4BMAD)之间的相关性,旨在初步探讨青少年AS早期骨量、骨密度研究的相关因素和评价指标。方法选择男性青少年强直性脊柱炎早期病例31例,获得年龄、身高、体质量、BMI,应用双能X线骨密度仪(DEXA)检测L1-4BMC,L1-4BMD,并计算L1-4BMAD;采用相关和回归分析研究多因素相关性。结果相关和回归分析表明,身高(P=0.000)和BMI(P=0.009)因素进入L1-4BMC回归方程(R=0.759,Radj2=0.545,P=0.000<0.01),其中身高是L1-4BMC回归方程的关键因素(R=0.676,Radj2=0.439,P=0.000)。另外,年龄、身高、体质量和BMI4因素中只有体质量因素被纳入L1-4BMD回归方程(R=0.657,Radj2=0.412,P=0.000)和L1-4BMAD回归方程(R=0.551,Radj2=0.280,P=0.001)。身高和BMI与L1-4BMC显著正相关,体质量则与L1-4BMD和L1-4BMAD呈显著正相关。结论身高和体质量因素即成为青少年AS早期骨矿含量和骨密度的重要相关因素。
Objective To study the early age, height, body mass, body mass index (BMI) and L1-4 bone mineral content (L1-4BMC), L1-4 BMD (L1-4 BMD) in adolescent with ankylosing spondylitis , L1-4 volume apparent bone mineral density (L1-4BMAD) between the correlation, aimed to initially explore the juvenile AS early bone mass, bone mineral density related factors and evaluation indicators. Methods Thirty-one cases of early-onset ankylosing spondylitis in male adolescents were enrolled in this study. Age, height, body mass and BMI were measured. L1-4BMC and L1-4BMD were detected by dual-energy X-ray absorptiometry (DEXA) Correlation and regression analysis studied multivariate correlations. Results Correlation and regression analysis showed that height (P = 0.000) and BMI (P = 0.009) entered L1-4 BMC regression equation (R = 0.759, Radj2 = 0.545, P = 0.000 <0.01) The key factors of the equation (R = 0.676, Radj2 = 0.439, P = 0.000). In addition, only the body mass factors of age, height, body mass and BMI4 were included in L1-4BMD regression equation (R = 0.657, Radj2 = 0.412, P = 0.000) and L1-4BMAD regression equation , P = 0.001). There was a significant positive correlation between height and BMI with L1-4BMC, while body mass was positively correlated with L1-4BMD and L1-4BMAD. Conclusion The height and body mass factors are the important correlates of early bone mineral content and bone mineral density in adolescents.