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我们采用聚合酶链反应(ＰＣＲ)和ＰＣＲ单链构象多态性分析(ＳＳＣＰ)技术研究了国内儿童急性白血病细胞中ＭＴＳ1基因的纯合性缺失和突变情况,以探讨ＭＴＳ1基因在儿童急性白血病发生、发展中的变化规律和意义。对象和方法1 研究对象 儿童急性白血病患者79例,均为1988年8月
We investigated the homozygous deletion and mutation of MTS1 gene in children with acute leukemia in China by polymerase chain reaction (PCR) and single-strand conformation polymorphism (PCR) based on single strand conformation polymorphism (PCR-SSCP) to explore the role of MTS1 gene in childhood acute leukemia , The changing law and significance of development. Subjects and methods A study of 79 patients with acute leukemia in children, all in August 1988