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目的:对产褥期回访细菌性阴道病(BV)患者采用乳酸杆菌活菌制剂治疗,观察其治愈率、复发率及治疗效果,并分析其对改善阴道内环境的作用。方法:对402例产褥期妇女常规筛查出BV患者65例为实验组,对照组32例。实验组采用活性乳酸菌阴道胶囊2枚(0.25g/枚),对照组采用甲硝唑栓1枚,均为每日1次阴道上药,计10天。结果:实验组与对照组的临床治愈率分别为92.31%(60/65)、84.38%(27/32),总有效率分别为95.38%(62/65)、93.75%(30/32),差异均无显著性意义(p>0.05);复发率分别为3.08%,34.37%,差异有显著性意义(P<0.05);两组治疗后阴道乳酸杆菌的检出率比较有显著差异;阴道乳酸杆菌的检出数量与细菌性阴道病复发率之间存在负相关。结论:应用乳酸杆菌活菌制剂治疗BV短期疗效与对照组基本相同,但治疗后阴道乳酸扦菌的恢复程度明显优于对照组,复发率明显低于传统疗法,阴道内环境也得到明显改善。
OBJECTIVE: To treat the patients with bacterial vaginosis (BV) in postpartum period by treatment with live Lactobacillus preparation and to observe the cure rate, recurrence rate and treatment effect, and to analyze its effect on improving vaginal environment. Methods: A total of 402 cases of BV patients were randomly divided into experimental group (n = 32) and control group (n = 32). In the experimental group, 2 lactic acid bacteria vaginal capsules (0.25g / capsule) were used, while in the control group, 1 metronidazole suppository was used, all of which were vaginal drugs once daily for 10 days. Results The clinical cure rates of the experimental group and the control group were 92.31% (60/65) and 84.38% (27/32), respectively. The total effective rates were 95.38% (62/65) and 93.75% (30/32), respectively (P> 0.05). The recurrence rates were 3.08% and 34.37% respectively, the difference was significant (P <0.05). The detection rate of Lactobacillus vaginalis between the two groups was significantly different There is a negative correlation between the number of detected Lactobacilli and the recurrence rate of bacterial vaginosis. Conclusion: The short-term efficacy of Lactobacillus treatment of BV is basically the same as that of the control group. However, the recovery rate of vaginal lactic acid bacteria was significantly better than that of the control group after treatment. The recurrence rate was significantly lower than that of the traditional therapy and the vaginal environment was also significantly improved.