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本实验探讨大白鼠肠系膜上动脉夹闭休克时输注SOD的抗脂质过氧化作用和细胞保护效应。松夹1h,实验组肠和心肌MDA较对照组明显升高(P<0.05),而SOD治疗组肠和心肌MDA明显低于实验组(P<0.05),与对照组无显著差异(P>0.05)。松夹2h,实验组肠、心、肝、肺MDA均明显高于对照组(P<0.5～0.01),而SOD治疗组肠、心、肺MDA仍低于实验组(P<0.05),但较对照组明显升高(P<0.05)。此外,SOD治疗组血浆β-葡萄糖醛酸酶和酸性磷酸酶明显低于实验组,动物存活时间明显延长。
This experiment was to investigate the anti-lipid peroxidation and cytoprotective effects of SOD infusion in the superior mesenteric artery of rats. Compared with the control group, the MDA content in the experimental group was significantly higher than that in the control group (P <0.05), while the MDA content in the experimental group was significantly lower than that in the experimental group (P < 0.05). The contents of MDA in the intestines, heart, liver and lungs in the experimental group were significantly higher than those in the control group (P <0.5-0.01), while those in the SOD group were still lower than those in the experimental group (P <0.05) Than the control group was significantly higher (P <0.05). In addition, the plasma levels of β-glucuronidase and acid phosphatase in SOD-treated group were significantly lower than those in the experimental group, and their survival time was significantly longer.