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目的分析介入栓塞术治疗脑动静脉畸形(BAVM)的疗效及效果影响因素。方法 86例行介入栓塞术治疗BAVM患者设为研究组,72例予以内减压手术治疗脑外伤患者作为对照组,对比两组脑组织细胞因子表达情况,并分析相关影响因素。结果研究组血管内皮生长因子(VEGF)、肿瘤坏死因子-α(TFN-α)、基质金属蛋白酶-9(MMP-9)及白细胞介素-6(IL-6)表达均高于对照组(P<0.05);介入栓塞术治疗效果与VEGF、TFN-α、IL-6相关性较高(r=0.4011、0.4299、0.4447)。结论介入栓塞术治疗BAVM可有效降低免疫细胞因子表达,且临床变化与TFN-α、IL-6及VEGF显著相关。
Objective To analyze the efficacy and effect of interventional embolization on cerebral arteriovenous malformation (BAVM). Methods Eighty-six patients with BAVM undergoing interventional embolization were enrolled in the study group, and 72 underwent intra-decompression surgery as brain injury control group. The expression of cytokines was compared between the two groups and the related factors were analyzed. Results The expression of vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in the study group were higher than those in the control group P <0.05). The effect of interventional embolization was significantly correlated with VEGF, TFN-α and IL-6 (r = 0.4011,0.4299,0.4447). Conclusion Interventional embolization of BAVM can effectively reduce the expression of immune cytokines, and the clinical changes are significantly associated with TFN-α, IL-6 and VEGF.