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肥胖和非肥胖的非胰岛素依赖型(Ⅱ型)糖尿病患者,胰岛素抵抗是一种特征性表现。胰岛素抵抗可由于胰岛素分子异常或胰岛素元不能充分转化为胰岛素,循环中存在抗胰岛素物质(生长激素、考的索、胰高糖素、儿茶酚胺,直接对抗胰岛素或胰岛素受体的抗体);或靶组织缺乏胰岛素作用(胰岛素受体或受体后缺陷)等所致。作者认为:胰岛素抵抗的Ⅱ型糖尿病,多数是由于靶组织的胰岛素作用不正常,这种不正常,可分为受体和受体后缺陷。
Insulin resistance is a characteristic manifestation of obese and non-obese non-insulin-dependent (type II) diabetics. Insulin resistance may be due to abnormalities in insulin molecules or insufficient conversion of insulin to insulin with circulating anti-insulin substances (growth hormone, testoxazole, glucagon, catecholamines, antibodies directed against insulin or insulin receptors) or targets Tissue lack of insulin action (insulin receptor or post-receptor defects) caused. The authors believe that: insulin-resistant type 2 diabetes, mostly due to abnormal insulin target tissue, this abnormal, can be divided into receptor and receptor defects.