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目的：研究宫颈癌浸润淋巴细胞（ＴｉＬ）、Ｌａｎｇｅｒｈａｎｓ细胞（ＬＣ）分布及与淋巴细胞活性标记物ＨＬＡ－ＤＲ和转铁蛋白受体（ＴｆＲ）的关系。方法：应用ＣＤ４，ＣＤ８，ＯＫＴ１１，ＯＫＴ９，ＨＬＡ－ＤＲ和Ｓ－１００抗体及ＡＢＣ免疫组化法。结果：ＣＤ４，ＣＤ８，ＯＫＴ１１阳性细胞随肿瘤发展而增多，并和转铁蛋白受体（ＴｆＲ）及ＨＬＡ－ＤＲ阳性表达密切关联。ＬＣ细胞数目随肿瘤分期增高和ＴｉＬ密度增加而增多。结论：ＴｉＬ和ＬＣ在宫颈癌中数量增多和活性增高的作用尚不清楚，它可能是宫颈癌局部的免疫反应表现。
Objective: To investigate the distribution of cervical lymphocyte infiltration (LIL), Langerhans cells (LC) and their relationship with lymphocyte activity markers HLA-DR and transferrin receptor (TfR). Methods: CD4, CD8, OKT11, OKT9, HLA-DR and S-100 antibodies and ABC immunohistochemical method were used. Results: The positive cells of CD4, CD8 and OKT11 increased with tumor development, and were closely associated with the expression of TfR and HLA-DR. The number of LC cells increased with the staging of tumor and the increase of TiL density. Conclusion: The role of TiL and LC in the increase of cervical cancer and its activity is unclear, which may be the local immune response of cervical cancer.