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目的:探讨南充市原发性肝癌(hepatocellular carcinoma,HCC)的危险因素,为我市预防肝癌的发生提供科学依据。方法:应用病例对照研究的方法,对南充市新诊断的226例原发性肝癌患者进行1∶1配对,通过条件Logist ic回归单因素和多因素分析筛选肝癌的主要危险因素。结果:单因素条件logist ic回归分析发现有22个因素与肝癌的发生有关;多因素条件logistic回归分析发现有10个主要危险因素与肝癌的发生有关,即HbsAg阳性(OR=5.83,95%C.I.1.23-2.78)、慢性乙肝病史(OR=4.92,95%C.I.3.28-7.03)、肝硬化(OR=4.21,95%C.I.4.75-7.23)、吸烟(OR=2.87,95%C.I.1.31-4.72)、吸烟量≥20包*年(OR=3.89,95%C.I.2.97-4.67)、饮酒(OR=3.03,95%C.I.1.23-5.21)、饮酒≥250g/日(OR=3.91,95%C.I.1.61-5.39)、饮地面水(OR=2.67,95%C.I.1.28-4.33)、肿瘤家族史(OR=2.98,95%C.I.1.84-3.63)、精神压抑(OR=1.84,95%C.I.1.02-3.81)。常吃腌菜、酸菜(OR=1.24,95%C.I.0.68-2.64)是一个可能的危险因素,尚待进一步探讨。结论:肝癌的发生是多种因素综合作用的结果,控制危险因素可减少肝癌的发病率。
Objective: To explore the risk factors of hepatocellular carcinoma (HCC) in Nanchong City and provide a scientific basis for the prevention of hepatocellular carcinoma in our city. Methods: A case-control study was conducted to identify 226 newly diagnosed patients with primary hepatocellular carcinoma in Nanchong City, and to screen the major risk factors of hepatocellular carcinoma by conditional Logistic regression with univariate and multivariate analysis. Results: Logistic regression analysis showed that 22 factors were related to the occurrence of HCC. Multivariate conditional logistic regression analysis showed that 10 major risk factors were related to the occurrence of HCC, ie, HbsAg positive (OR = 5.83, 95% CI 1.23-2.78), chronic hepatitis B (OR = 4.92,95% CI 3.28-7.03), cirrhosis (OR = 4.21,95% CI 4.75-7.23), smoking (OR = 2.87,95% CI 1.31-4.72) (OR = 3.89, 95% CI2.97-4.67), alcohol consumption (OR = 3.03, 95% CI 1.23-5.21), alcohol consumption ≥250g / day (OR = 3.91,95% CI 1.61-5.39 ), Drinking surface water (OR = 2.67,95% CI 1.28-4.33), family history of cancer (OR = 2.98,95% CI 1.84-3.63) and depression (OR = 1.84,95% CI 1.02-3.81). Eat pickles, sauerkraut (OR = 1.24,95% C.I.0.68-2.64) is a possible risk factor to be further explored. Conclusion: The occurrence of hepatocellular carcinoma is the result of the combination of multiple factors. Controlling the risk factors can reduce the incidence of liver cancer.