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乙醇代谢的主要途径首先是在肝中由乙醇脱氢酶(ADH)起氧化反应,然后由醛脱氢酶(ALDH)作用产生乙酸和NADH。已初步证明ADH由三个结构基因位点所控制,而ALDH经淀粉凝胶电泳研究可分为二条主带。酶1和酶2的Km不同,阳离子对它们有不同的抑制或激活作用,二个酶的分子量也不同,约相差20,000。本文采用取自101个中国人和53个印度人尸体解剖的肝标本。他们的年龄范围从
The primary pathway for ethanol metabolism is primarily oxidative oxidation by alcohol dehydrogenase (ADH) in the liver followed by aldehyde dehydrogenase (ALDH) to produce acetic acid and NADH. ADH has been initially proved to be controlled by three structural gene loci, while ALDH can be divided into two main bands by starch gel electrophoresis. The Km of enzyme 1 is different from that of enzyme 2, and the cations have different inhibitory or activating effects on them. The molecular weights of the two enzymes are also different, about 20,000. In this study, autopsy specimens from 101 Chinese and 53 Indians were collected. Their age range from