FHIT基因是近年来发现的基因,包括肺癌在内的多种肿瘤,特别是上皮性因环境致癌因素导致的肿瘤中常可检测出FHIT基因的纯合性和杂合性缺失,对研究肺癌特别是吸烟相关性肺癌的发生机制、早期诊断和治疗的探索提供了新的思路。它可能通过与P53无关的途径诱导凋亡,从而抑制肿瘤的发生。 FHIT gene is found in recent years, a variety of tumors, including lung cancer, especially epithelial cancer caused by environmental factors can often be detected FHIT gene homozygosity and loss of heterozygosity for the study of lung cancer, especially Smoking-related lung cancer pathogenesis, early diagnosis and treatment of exploration provides a new way of thinking. It may induce apoptosis through a pathway unrelated to P53, thereby inhibiting tumorigenesis.