过去20年,登革出血热(DHF)已成为流行病学、病毒学和免疫学研究的重要课题。其病因及免疫机理在发病机理中可能起何种作用,也成为争论的焦点。本文评述目前关于这个问题的一些认识。目前,整个东南亚和南太平洋地区都发现了这种疾病。从1956年起大约35万人因本病住院,1.2万人死亡。它对全世界大约15亿人口仍然是一个潜在威胁。 Over the past two decades, dengue haemorrhagic fever (DHF) has become an important topic in epidemiological, virological and immunological research. The etiology and immune mechanism in pathogenesis may play a role, has also become the focus of controversy. This article reviews some of the current understandings on this issue. Currently, the disease is found throughout South-East Asia and the South Pacific. About 35 million people have been hospitalized since 1956 and 12,000 died. It remains a potential threat to some 1.5 billion people around the world.