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目的分析新生儿窒息后血清总胆汁酸(TBA)变化及其临床意义。方法检测92例窒息新生儿和19例无窒息史正常新生儿的血清TBA、总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)和γ-谷氨酰转移酶(γ-GT)。结果窒息组血清TBA及其他肝功能指标(TBIL、DBIL、ALT、AST、ALP、γ-GT),与正常对照组比较均无显著性差异(P均>0.05)。轻度窒息组与重度窒息组比较,轻度窒息组和重度窒息组分别与对照组比较,差异也均无显著性(P均>0.05)。结论血清TBA与新生儿窒息及其窒息程度无明显关系。
Objective To analyze the change of serum total bile acid (TBA) after neonatal asphyxia and its clinical significance. Methods The levels of serum TBA, total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT) and aspartate in 92 neonates with asphyxia and 19 normal neonates without asphyxia were detected. Aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (γ-GT). Results Serum TBA and other liver function indexes (TBIL, DBIL, ALT, AST, ALP, γ-GT) in asphyxia group were not significantly different from those in normal control group (all P> 0.05). Mild asphyxia group and severe asphyxia group, mild asphyxia group and severe asphyxia group compared with the control group, the difference was not significant (P all> 0.05). Conclusion There is no significant relationship between serum TBA and neonatal asphyxia and asphyxia.