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目的观察比索洛尔对慢性心力衰竭患者血浆脑钠肽(BNP)水平及左心室收缩功能的变化。方法慢性心力衰竭患者160例,分成2组,比索洛尔组(88例),对照组(72例),应用酶联免疫吸附法(ELISA)测定治疗前1个月、3个月、6个月时血浆BNP;心脏超声诊断仪测量同期心脏结构和心功能。结果治疗前慢性心力衰竭患者BNP水平均高于正常;治疗后1个月血浆BNP水平较治疗前下降(P<0.05),3个月、6个月明显下降(P<0.01)。治疗后6个月两组左心室舒张内径、左心室收缩末内径及左心室射血分数与治疗前相比均有明显差异(P<0.05)。结论慢性心力衰竭患者血浆BNP水平可以作为治疗心力衰竭的一个可靠的观察指标,比索洛尔治疗慢性心力衰竭效果较好。
Objective To observe the changes of plasma brain natriuretic peptide (BNP) and left ventricular systolic function in patients with chronic heart failure. Methods One hundred and sixty patients with chronic heart failure were divided into 2 groups: bisoprolol group (88 cases) and control group (72 cases) Month plasma BNP; cardiac ultrasound system to measure cardiac structure and cardiac function over the same period. Results BNP levels in patients with chronic heart failure before treatment were significantly higher than those in normal controls. Plasma BNP level decreased 1 month after treatment (P <0.05), and significantly decreased at 3 months and 6 months (P <0.01). The left ventricular diastolic diameter, left ventricular end-systolic diameter, and left ventricular ejection fraction at 6 months after treatment were significantly different from those before treatment (P <0.05). Conclusions BNP levels in patients with chronic heart failure can be used as a reliable indicator of heart failure. Bisoprolol is effective in treating chronic heart failure.