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目的:探讨甘氨双唑钠(CMNa)在ⅣB期鼻咽癌放射治疗的增敏作用和临床应用价值。方法:选择ⅣB期鼻咽癌,面颈联合野加双下颈前后对穿照射36Gy后,颈部转移淋巴结残留≥5cm的患者40例,分为前瞻性分析试验组(CMNa+放疗)和对照组各20例。试验组采用CMNa800mg/m2,用100mL生理盐水稀释溶解,于30min内静脉滴完,在60min内进行3D-CRT放疗。对照组仅行3D-CRT放疗。结果:放疗70Gy结束后,评定疗效,颈部转移淋巴结缓解率(CR+PR):试验组90%(18/20),对照组55%(11/20),P=0.01;原发灶(T)缓解率:试验组95%(19/20),对照组65%(13/20),P=0.02。结论:CMNa对鼻咽癌有良好的放疗增敏作用,特别是对于颈部淋巴结转移灶大的患者,近期疗效明显,且药物耐受性好。远期效果有待进一步观察。
Objective: To investigate the sensitizing effect and clinical value of glycididazole sodium (CMNa) in radiation therapy of stage ⅣB nasopharyngeal carcinoma. Methods: Forty patients with stage ⅣB nasopharyngeal carcinoma were selected. Forty patients with neck metastasis lymph node residual ≥5cm were divided into two groups: prospective study group (CMNa + radiotherapy) and control group 20 cases each. The experimental group with CMNa800mg / m2, diluted with 100mL saline dissolved in 30min intravenous drip, 3D-CRT within 60min radiotherapy. The control group only treated with 3D-CRT radiotherapy. Results: After 70 Gy of radiotherapy, CR + PR was evaluated in 90% (18/20) of the experimental group and 55% (11/20) in the control group, P = T) Remission rate: 95% (19/20) in the test group and 65% (13/20) in the control group, P = 0.02. CONCLUSIONS: CMNa has a good radiosensitizing effect on nasopharyngeal carcinoma. Especially for patients with large metastasis of cervical lymph nodes, the curative effect is obvious and the drug tolerance is good. Long-term results need to be further observed.