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本研究应用 nm2 3- H1 单克隆抗体免疫组化技术对 30例卵巢上皮性癌进行 nm2 3-H1 癌基因蛋白测定 ,以探讨该基因在卵巢癌组织的表达及其与临床病理特征的关系 ,结果显示有8例胞浆染色阳性 ,占 2 6 .6 7% , - 期阳性率为 42 .91% , - 期阳性率为 12 .5 0 % ,差异有显著性 (P<0 .0 1) ,多见于高、中分化 ,病程短 ,临床期别早的患者 ,取 13例患者原发灶与转移灶同时检测 ,11例均为阴性 ,2例原发灶阳性而转移灶阴性 ,提示在卵巢癌细胞侵蚀与转移过程中 ,nm2 3- H1 基因可能是抑制因素之一。
In this study, nm2 3-H1 oncoprotein was detected in 30 cases of epithelial ovarian cancer using nm2 3-H1 monoclonal antibody immunohistochemistry to investigate the expression of nm23 3-H1 in ovarian cancer and its relationship with clinicopathological features, The results showed that 8 cases of cytoplasm staining positive, accounting for 26.76%, - the positive rate was 42.91%, - positive rate was 12.5%, the difference was significant (P <0. ), More common in high, moderately differentiated, short course of disease, early clinical stage, take 13 cases of primary tumor and metastasis simultaneously detected in 11 cases were negative, 2 cases of primary positive and metastatic lesions negative, suggesting In ovarian cancer cell erosion and metastasis, nm2 3-H1 gene may be one of the inhibitory factors.