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一、脑膜炎球菌感染发病的素质因素近年来对主要组织相容性抗原(HLA)与人类各种疾病的关系进行了广泛研究,目前已经证明 HLA参与了各种免疫反应,与许多疾病的发病有关。等应用淋巴毒素试验对104例脑膜炎球菌感染患儿 HLA 的研究表明,HLA 系统表型不同的人,对脑膜炎球菌的敏感性不同。具有 HLA-BW_(16)或 HLA-B_(12)表型者,发生脑膜炎球菌感染的危险度,较具有 HLA-A_1者分别大6倍和3倍。该项研究对于脑膜炎球菌感染的个体预防,尤其是选择性的菌苗接种具有重要意义。
First, the quality of factors affecting the incidence of meningococcal infection In recent years, major histocompatibility antigens (HLA) and human diseases, a wide range of research has been proved that HLA is involved in a variety of immune responses, and many diseases related. Application of lymphotoxin test 104 cases of children with meningococcal infection in children with HLA showed that different phenotypes of HLA system, different sensitivity to meningococcus. Those with HLA-BW_ (16) or HLA-B_ (12) phenotypes had a 6-fold and 3-fold greater risk of developing meningococcal infection, respectively, than those with HLA-A_1. This study is of great importance to individual prevention of meningococcal infections, especially selective vaccination.