动物大脑中动脉(ＭＣＡ)闭塞卒中模型存在皮质、基底节和白质梗死等病变。几乎所有的神经保护药都是通过受体介导或与胶质、大脑白质关系不确定的神经细胞内机制发挥作用,但几乎所有药物保护均限于大脑皮质。因此,需要进一步改进评估轴索完整性的技术,因目前尚无活体资料?.. Animal models of occlusion of the middle cerebral artery (MCA) include cortical, basal ganglia, and white matter infarcts. Almost all neuroprotective drugs play a role in receptor-mediated or intracellular neuronal mechanisms that have an indeterminate relationship with glia and white matter, but almost all drug protection is limited to the cerebral cortex. Therefore, there is a need to further improve the technique for assessing the integrity of axons, as no in vivo information is currently available.