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为探讨中重度新生儿缺氧缺血性脑病（ＮＨＩＥ）时内环境的变化，我们观察３２例中重度ＮＨＩＥ急性期、恢复期血清多项生化指标的变化，并与正常新生儿组做对照。结果：中重度ＮＨＩＥ在急性期存在血乳酸和血氨增高，血清钙离子和过氧化物歧化酶（ＳＯＤ）降低，心肌酶活性增高，血尿素氮增高，血钠降低。二氧化碳结合力减低。研究表明：中重度ＮＨＩＥ患儿有多项血生化改变，说明有多脏器的影响及损伤，为ＮＨＩＥ的综合治疗提供了理论依据
To investigate the changes of the internal environment in moderate-severe neonatal hypoxic-ischemic encephalopathy (NHIE), we observed the changes of serum biochemical parameters in 32 moderate-severe NHIE acute and convalescent phases and compared them with normal neonates. Results: The moderate and severe NHIE had increased levels of blood lactic acid and ammonia in the acute phase, decreased serum calcium and superoxide dismutase (SOD), increased myocardial enzyme activity, increased blood urea nitrogen and decreased serum sodium. Carbon dioxide binding decreased. Studies have shown that: children with moderate-to-severe NHIE have a number of blood biochemical changes, indicating the impact of multiple organs and damage, provide a theoretical basis for the comprehensive treatment of NHIE