甘草次酸及其衍生物的制剂在临床上用作抗溃疡和抗过敏剂,最近发现其衍生物SNMC有治疗慢性肝炎作用.然而甘草酸和甘草次酸有类可的松作用,长期大剂量服用可引起伪醛固酮过多症的副作用.已知其机理是C环上的11-酮-△~(12)可与可的松甾体A环的△~4-3-酮竞争大鼠肝脏的△~4-还原酶,显著抑制可 Glycyrrhetinic acid and its derivatives in the clinical use of anti-ulcer and anti-allergic agents, recently found that its derivatives SNMC treatment of chronic hepatitis.But glycyrrhizin and glycyrrhetinic have cortisone effect, long-term high-dose It is known that its mechanism is that the 11-keto-Δ12 on the C-ring competes with the 4-4-keto-methyl of the cortisone steroid A ring in the rat liver △ 4-reductase, significantly inhibited