一、肝素的功能与结构肝素由于可有效地加速抗凝血酶与止血机制中的丝氨酸蛋白酶作用,而发挥其作为抗凝剂的功能。Rosenberg等曾证明粘多糖的作用是与抗凝血酶结合从而以变构的方式增大酶-抑制剂复合物的形成速率。Gitel和Holmer,曾提出肝素开始即被抗凝血酶结合,继而作为蛋白酶抑制剂接近止血体系中的丝氨酸蛋白酶。Griffith等则认为粘多糖首先与止血体系中的丝氨酸蛋白酶结合,形成的复合物 First, the function and structure of heparin Heparin as antithrombin can effectively accelerate the role of serotonin in the mechanism of hemostasis, and play its role as an anticoagulant. Rosenberg et al. Have demonstrated that mucopolysaccharides act by binding antithrombin to increase the rate of enzyme-inhibitor complex formation in an allosteric manner. Gitel and Holmer have proposed that heparin is initially bound by antithrombin, which in turn acts as a protease inhibitor to approximate the serine protease in the hemostatic system. Griffith so that mucopolysaccharides and hemostatic system first serine protease binding, the formation of complexes