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目的观察早期(出血后3d)应用疏血通注射液对脑出血患者血肿吸收、血肿周围水肿面积、神经功能恢复以及血液中纤维蛋白原含量的影响。方法将85例患者随机分对照组43例,治疗组42例。对照组给予降颅压,控制血压、血糖,防止出血等常规治疗;治疗组在常规治疗的基础上,于出血后3d加用疏血通注射液静脉滴注,1次/d,连续15d。分别于治疗前、治疗后4d与14d行CT检查测量血肿体积、血肿周围水肿面积,并参照美国国立卫生研究院脑卒中量表(NIHSS)进行NIHSS评分,同时检测血液中纤维蛋白原含量。结果治疗第4天血肿体积、血肿周围水肿面积、神经功能评分2组差异均无统计学意义(P均>0.05);治疗第14天,治疗组血肿体积明显缩小,血肿周围水肿面积减少,神经功能明显改善,与对照组比较差异有统计学意义(P<0.01或P<0.05)。治疗第4天,2组血纤维蛋白原含量无明显变化(P>0.05);治疗第14天治疗组血纤维蛋白原含量明显下降(P<0.01)。结论早期应用疏血通能促进脑出血时的血肿吸收、减少血肿周围水肿面积、改善神经功能以及降低血液中纤维蛋白原含量。
Objective To observe the effect of Shuxuetong injection on the hematoma absorption, the area around the hematoma, the recovery of neurological function and the content of fibrinogen in patients with early cerebral hemorrhage (3d after hemorrhage). Methods A total of 85 patients were randomly divided into control group (n = 43) and treatment group (n = 42). Control group was given intracranial pressure, blood pressure, blood glucose, to prevent bleeding and other conventional treatment; the treatment group on the basis of conventional treatment, add blood Shuxuetong injection intravenously after 3d, 1 / d, continuous 15d. The volume of hematoma, the area of edema around hematoma were measured by CT examination before treatment, 4d and 14d after treatment, and NIHSS score was measured according to National Institutes of Health Stroke Scale (NIHSS). Meanwhile, the content of fibrinogen in blood was measured. Results On the 4th day after treatment, the hematoma volume, edema area around the hematoma, and neurological function score were not significantly different between the two groups (all P> 0.05). On the 14th day after treatment, the hematoma volume of the treatment group was significantly reduced, the edema area around the hematoma was reduced, Function was significantly improved, compared with the control group, the difference was statistically significant (P <0.01 or P <0.05). On the fourth day after treatment, there was no significant change in the content of fibrinogen in the two groups (P> 0.05). On the 14th day, the content of fibrinogen in the treatment group was significantly decreased (P <0.01). Conclusion Shuxuetong early application of hematoma can promote intracranial hemorrhage, reduce the area around the hematoma edema, improve nerve function and reduce blood fibrinogen.